Neutrophilic Urticaria With Systemic Inflammation | Zendy

Hrishikesh Belani | Zendy; Lianne S. Gensler | Zendy; Urmila D. Bajpai | Zendy; Eric Meinhardt | Zendy; Jonathan Graf | Zendy; Laura Pincus | Zendy; Kieron Leslie | Zendy

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Neutrophilic Urticaria With Systemic Inflammation

Author(s) -

Hrishikesh Belani,

Lianne S. Gensler,

Urmila D. Bajpai,

Eric Meinhardt,

Jonathan Graf,

Laura Pincus,

Kieron Leslie

Publication year - 2013

Publication title -

jama dermatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.128

H-Index - 166

eISSN - 2168-6084

pISSN - 2168-6068

DOI - 10.1001/jamadermatol.2013.2705

Subject(s) - medicine , anakinra , antihistamine , dermatology , systemic inflammation , colchicine , arthritis , gastroenterology , discontinuation , inflammation , immunology , disease

Predominantly neutrophilic infiltrates are seen in a subset of patients with urticaria. The lesions tend to be less itchy and poorly responsive to standard therapy, including antihistamines. We describe 2 patients having neutrophilic urticaria with systemic inflammation (NUSI) without known connective tissue disorder or malignancy. We propose the term NUSI to help classify a previously undefined multisystemic inflammatory entity likely mediated by interleukin 1 (IL-1).

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