Complement Factor H Polymorphism, Complement Activators, and Risk of Age-Related Macular Degeneration | Zendy

Dominiek D. G. Despriet | Zendy; Caroline C. W. Klaver | Zendy; Jacqueline C.M. Witteman | Zendy; Arthur A. Bergen | Zendy; Isabella Kardys | Zendy; Moniek P.M. de Maat | Zendy; Sharmila S. Boekhoorn | Zendy; Johannes R. Vingerling | Zendy; Albert Hofman | Zendy; Ben A. Oostra | Zendy; André G. Uitterlinden | Zendy; Theo Stijnen | Zendy; Cornelia M. van Duijn | Zendy; Paulus T.V.M. de Jong | Zendy

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Complement Factor H Polymorphism, Complement Activators, and Risk of Age-Related Macular Degeneration

Author(s) -

Dominiek D. G. Despriet,

Caroline C. W. Klaver,

Jacqueline C.M. Witteman,

Arthur A. Bergen,

Isabella Kardys,

Moniek P.M. de Maat,

Sharmila S. Boekhoorn,

Johannes R. Vingerling,

Albert Hofman,

Ben A. Oostra,

André G. Uitterlinden,

Theo Stijnen,

Cornelia M. van Duijn,

Paulus T.V.M. de Jong

Publication year - 2006

Publication title -

jama

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.688

H-Index - 680

eISSN - 1538-3598

pISSN - 0098-7484

DOI - 10.1001/jama.296.3.301

Subject(s) - medicine , factor h , macular degeneration , odds ratio , confidence interval , rotterdam study , population , allele , hazard ratio , c reactive protein , risk factor , prospective cohort study , immunology , complement system , inflammation , genetics , ophthalmology , gene , biology , antibody , environmental health

The evidence that inflammation is an important pathway in age-related macular degeneration (AMD) is growing. Recent case-control studies demonstrated an association between the complement factor H (CFH) gene, a regulator of complement, and AMD.

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