Urinary Placental Growth Factor and Risk of Preeclampsia | Zendy

Richard J. Levine | Zendy

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Urinary Placental Growth Factor and Risk of Preeclampsia

Author(s) -

Richard J. Levine

Publication year - 2005

Publication title -

jama

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.688

H-Index - 680

eISSN - 1538-3598

pISSN - 0098-7484

DOI - 10.1001/jama.293.1.77

Subject(s) - medicine , preeclampsia , placental growth factor , proteinuria , urinary system , gestational age , creatinine , urine , endocrinology , pregnancy , soluble fms like tyrosine kinase 1 , vascular endothelial growth factor , vegf receptors , kidney , genetics , biology

Preeclampsia may be caused by an imbalance of angiogenic factors. We previously demonstrated that high serum levels of soluble fms-like tyrosine kinase 1 (sFlt1), an antiangiogenic protein, and low levels of placental growth factor (PlGF), a proangiogenic protein, predict subsequent development of preeclampsia. In the absence of glomerular disease leading to proteinuria, sFlt1 is too large a molecule to be filtered into the urine, while PlGF is readily filtered.

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