Open AccessAssociation of Serum Digoxin Concentration and Outcomes in Patients With Heart Failure
Author(s) -
Saif S. Rathore,
Jeptha P. Curtis,
Yongfei Wang,
Michael R. Bristow,
Harlan M. Krumholz
Publication year - 2003
Publication title -
jama
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.688
H-Index - 680
eISSN - 1538-3598
pISSN - 0098-7484
DOI - 10.1001/jama.289.7.871
Subject(s) - medicine , digoxin , ejection fraction , heart failure , placebo , digitalis , confidence interval , cardiology , mortality rate , randomized controlled trial , alternative medicine , pathology
The Digitalis Investigation Group (DIG) trial reported that digoxin provided no overall mortality benefit and only a modest reduction in hospitalizations among patients with heart failure and depressed left ventricular systolic function. The clinical outcomes associated with digoxin therapy at different serum concentrations in the DIG trial have not been assessed.
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