Open AccessGenetic Studies on Chromosome 12 in Late-Onset Alzheimer Disease
Author(s) -
William Wu
Publication year - 1998
Publication title -
jama
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.688
H-Index - 680
eISSN - 1538-3598
pISSN - 0098-7484
DOI - 10.1001/jama.280.7.619
Subject(s) - locus (genetics) , genetics , centimorgan , medicine , genetic linkage , disease , genotyping , genotype , chromosome , biology , gene mapping , gene
The only genetic locus universally accepted to be important as a risk factor for late-onset Alzheimer disease (AD) is the apolipoprotein E (APOE) locus on chromosome 19. However, this locus does not account for all the risk in late-onset disease, and a recent report has suggested a second locus on chromosome 12p11-12.
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