Open AccessEffect of Intravenous Zoledronic Acid on Tibiofemoral Cartilage Volume Among Patients With Knee Osteoarthritis With Bone Marrow Lesions
Author(s) -
Guoqi Cai,
Dawn Aitken,
Laura L Laslett,
JeanPierre Pelletier,
Johanne MartelPelletier,
Catherine Hill,
Lyn March,
Anita E. Wluka,
Yuanyuan Wang,
Benny Antony,
Leigh Blizzard,
Tania Winzenberg,
Flavia Cicuttini,
Graeme Jones
Publication year - 2020
Publication title -
jama
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.688
H-Index - 680
eISSN - 1538-3598
pISSN - 0098-7484
DOI - 10.1001/jama.2020.2938
Subject(s) - medicine , osteoarthritis , zoledronic acid , minimal clinically important difference , knee pain , placebo , magnetic resonance imaging , saline , surgery , randomized controlled trial , visual analogue scale , bone marrow , anesthesia , radiology , pathology , alternative medicine
A proof-of-principle study suggested that intravenous zoledronic acid may reduce knee pain and the size of bone marrow lesions in people with knee osteoarthritis, but data from large trials are lacking.
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