Effect of Vancomycin or Daptomycin With vs Without an Antistaphylococcal β-Lactam on Mortality, Bacteremia, Relapse, or Treatment Failure in Patients With MRSA Bacteremia | Zendy

Steven Y. C. Tong | Zendy; David Chien Lye | Zendy; Dafna Yahav | Zendy; Archana Sud | Zendy; James O. Robinson | Zendy; Jane Nelson | Zendy; Sophia Archuleta | Zendy; Matthew A. Roberts | Zendy; Alan Cass | Zendy; David L. Paterson | Zendy; Hong Foo | Zendy; Mical Paul | Zendy; Stephen Guy | Zendy; Adrian R Tramontana | Zendy; Genevieve Walls | Zendy; Stephen McBride | Zendy; Narin Bak | Zendy; Niladri Ghosh | Zendy; Benjamin A. Rogers | Zendy; Anna P. Ralph | Zendy; Jane Davies | Zendy; Patricia Ferguson | Zendy; Ravindra Dotel | Zendy; Genevieve McKew | Zendy; Timothy Gray | Zendy; Natasha E. Holmes | Zendy; Simon Smith | Zendy; Morgyn S. Warner | Zendy; Shirin Kalimuddin | Zendy; Barnaby Edward Young | Zendy; Naomi Runnegar | Zendy; David Andresen | Zendy; Nicholas Anagnostou | Zendy; Sandra Johnson | Zendy; Mark D. Chatfield | Zendy; Allen C. Cheng | Zendy; Vance G. Fowler | Zendy; Benjamin P. Howden | Zendy; Niamh Meagher | Zendy; David J. Price | Zendy; Sebastiaan J. van Hal | Zendy; Matthew O’Sullivan | Zendy; Joshua S. Davis | Zendy

Open Access

Effect of Vancomycin or Daptomycin With vs Without an Antistaphylococcal β-Lactam on Mortality, Bacteremia, Relapse, or Treatment Failure in Patients With MRSA Bacteremia

Author(s) -

Steven Y. C. Tong,

David Chien Lye,

Dafna Yahav,

Archana Sud,

James O. Robinson,

Jane Nelson,

Sophia Archuleta,

Matthew A. Roberts,

Alan Cass,

David L. Paterson,

Hong Foo,

Mical Paul,

Stephen Guy,

Adrian R Tramontana,

Genevieve Walls,

Stephen McBride,

Narin Bak,

Niladri Ghosh,

Benjamin A. Rogers,

Anna P. Ralph,

Jane Davies,

Patricia Ferguson,

Ravindra Dotel,

Genevieve McKew,

Timothy Gray,

Natasha E. Holmes,

Simon Smith,

Morgyn S. Warner,

Shirin Kalimuddin,

Barnaby Edward Young,

Naomi Runnegar,

David Andresen,

Nicholas Anagnostou,

Sandra Johnson,

Mark D. Chatfield,

Allen C. Cheng,

Vance G. Fowler,

Benjamin P. Howden,

Niamh Meagher,

David J. Price,

Sebastiaan J. van Hal,

Matthew O’Sullivan,

Joshua S. Davis

Publication year - 2020

Publication title -

jama

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.688

H-Index - 680

eISSN - 1538-3598

pISSN - 0098-7484

DOI - 10.1001/jama.2020.0103

Subject(s) - medicine , bacteremia , daptomycin , flucloxacillin , vancomycin , randomized controlled trial , clinical endpoint , cefazolin , intravenous therapy , surgery , antibiotics , staphylococcus aureus , genetics , bacteria , microbiology and biotechnology , biology

Methicillin-resistant Staphylococcus aureus (MRSA) bacteremia is associated with mortality of more than 20%. Combining standard therapy with a β-lactam antibiotic has been associated with reduced mortality, although adequately powered randomized clinical trials of this intervention have not been conducted.

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