Open AccessPredictive Accuracy of a Polygenic Risk Score Compared With a Clinical Risk Score for Incident Coronary Heart Disease
Author(s) -
Jonathan D. Mosley,
Deepak K. Gupta,
Jingyi Tan,
Jie Yao,
Quinn S. Wells,
Christian M. Shaffer,
Suman Kundu,
Cassianne RobinsonCohen,
Bruce M. Psaty,
Stephen S. Rich,
Wendy S. Post,
Xiuqing Guo,
Jerome I. Rotter,
Dan M. Roden,
Robert E. Gerszten,
Thomas J. Wang
Publication year - 2020
Publication title -
jama
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.688
H-Index - 680
eISSN - 1538-3598
pISSN - 0098-7484
DOI - 10.1001/jama.2019.21782
Subject(s) - medicine , framingham risk score , interquartile range , population , cohort , demography , disease , environmental health , sociology
Polygenic risk scores comprising millions of single-nucleotide polymorphisms (SNPs) could be useful for population-wide coronary heart disease (CHD) screening.
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