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Effect of Linagliptin vs Glimepiride on Major Adverse Cardiovascular Outcomes in Patients With Type 2 Diabetes
Author(s) -
Julio Rosenstock,
Steven E. Kahn,
Odd Erik Johansen,
Bernard Zinman,
Mark A. Espeland,
Hans J. Woerle,
Egon Pfarr,
Annett Keller,
Michaela Mattheus,
David Baanstra,
Thomas Meinicke,
Jyothis T. George,
Maximilian von Eynatten,
Darren K. McGuire,
Nikolaus Marx
Publication year - 2019
Publication title -
jama
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.688
H-Index - 680
eISSN - 1538-3598
pISSN - 0098-7484
DOI - 10.1001/jama.2019.13772
Subject(s) - medicine , glimepiride , linagliptin , type 2 diabetes , randomized controlled trial , diabetes mellitus , hazard ratio , stroke (engine) , metformin , myocardial infarction , insulin , endocrinology , confidence interval , mechanical engineering , engineering
Type 2 diabetes is associated with increased cardiovascular risk. In placebo-controlled cardiovascular safety trials, the dipeptidyl peptidase-4 inhibitor linagliptin demonstrated noninferiority, but it has not been tested against an active comparator.

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