Association of Genetic Variants in NUDT15 With Thiopurine-Induced Myelosuppression in Patients With Inflammatory Bowel Disease | Zendy

G Walker | Zendy; James Harrison | Zendy; Graham Heap | Zendy; Michiel Voskuil | Zendy; Vibeke Andersen | Zendy; Carl A. Anderson | Zendy; Ashwin N. Ananthakrishnan | Zendy; Jeffrey C. Barrett | Zendy; Laurent Beaugerie | Zendy; Claire Bewshea | Zendy; Andy T. Cole | Zendy; Fraser Cummings | Zendy; Mark Daly | Zendy; Pierre Ellul | Zendy; Richard N. Fedorak | Zendy; Eleonora A. Festen | Zendy; Timothy H. Florin | Zendy; Daniel R. Gaya | Zendy; Jonas Halfvarson | Zendy; Ailsa Hart | Zendy; Neel Heerasing | Zendy; Peter Hendy | Zendy; Peter M. Irving | Zendy; Samuel E. Jones | Zendy; Jukka Koskela | Zendy; James O. Lindsay | Zendy; John Mansfield | Zendy; Dermot McGovern | Zendy; Miles Parkes | Zendy; Richard Pollok | Zendy; S. Ramakrishnan | Zendy; David S. Rampton | Zendy; Manuel A. Rivas | Zendy; Richard K. Russell | Zendy; Michael Schultz | Zendy; Shaji Sebastian | Zendy; Philippe Seksik | Zendy; Abhey Singh | Zendy; Kenji So | Zendy; Harry Sokol | Zendy; Kavitha Subramaniam | Zendy; Anthony Todd | Zendy; Vito Annese | Zendy; Rinse K. Weersma | Zendy; Ramnik J. Xavier | Zendy; Rebecca Ward | Zendy; Michael N. Weedon | Zendy; James Goodhand | Zendy; Nicholas A. Kennedy | Zendy; Tariq Ahmad | Zendy

Open Access

Association of Genetic Variants in NUDT15 With Thiopurine-Induced Myelosuppression in Patients With Inflammatory Bowel Disease

Author(s) -

G Walker,

James Harrison,

Graham Heap,

Michiel Voskuil,

Vibeke Andersen,

Carl A. Anderson,

Ashwin N. Ananthakrishnan,

Jeffrey C. Barrett,

Laurent Beaugerie,

Claire Bewshea,

Andy T. Cole,

Fraser Cummings,

Mark Daly,

Pierre Ellul,

Richard N. Fedorak,

Eleonora A. Festen,

Timothy H. Florin,

Daniel R. Gaya,

Jonas Halfvarson,

Ailsa Hart,

Neel Heerasing,

Peter Hendy,

Peter M. Irving,

Samuel E. Jones,

Jukka Koskela,

James O. Lindsay,

John Mansfield,

Dermot McGovern,

Miles Parkes,

Richard Pollok,

S. Ramakrishnan,

David S. Rampton,

Manuel A. Rivas,

Richard K. Russell,

Michael Schultz,

Shaji Sebastian,

Philippe Seksik,

Abhey Singh,

Kenji So,

Harry Sokol,

Kavitha Subramaniam,

Anthony Todd,

Vito Annese,

Rinse K. Weersma,

Ramnik J. Xavier,

Rebecca Ward,

Michael N. Weedon,

James Goodhand,

Nicholas A. Kennedy,

Tariq Ahmad

Publication year - 2019

Publication title -

jama

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.688

H-Index - 680

eISSN - 1538-3598

pISSN - 0098-7484

DOI - 10.1001/jama.2019.0709

Subject(s) - thiopurine methyltransferase , medicine , genome wide association study , inflammatory bowel disease , odds ratio , pharmacogenetics , interquartile range , azathioprine , ulcerative colitis , cohort , genetic association , disease , gastroenterology , genotype , single nucleotide polymorphism , genetics , biology , gene

Use of thiopurines may be limited by myelosuppression. TPMT pharmacogenetic testing identifies only 25% of at-risk patients of European ancestry. Among patients of East Asian ancestry, NUDT15 variants are associated with thiopurine-induced myelosuppression (TIM).

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research