Association of Triglyceride-Lowering LPL Variants and LDL-C–Lowering LDLR Variants With Risk of Coronary Heart Disease | Zendy

Brian A. Ference | Zendy; John J.P. Kastelein | Zendy; Kausik K. Ray | Zendy; Henry N. Ginsberg | Zendy; M. John Chapman | Zendy; Chris J. Packard | Zendy; Ulrich Laufs | Zendy; Clare OliverWilliams | Zendy; Angela Wood | Zendy; Adam S. Butterworth | Zendy; Emanuele Di Angelantonio | Zendy; John Danesh | Zendy; Stephen J. Nicholls | Zendy; Deepak L. Bhatt | Zendy; Marc S. Sabatine | Zendy; Alberico L. Catapano | Zendy

Open Access

Association of Triglyceride-Lowering LPL Variants and LDL-C–Lowering LDLR Variants With Risk of Coronary Heart Disease

Author(s) -

Brian A. Ference,

John J.P. Kastelein,

Kausik K. Ray,

Henry N. Ginsberg,

M. John Chapman,

Chris J. Packard,

Ulrich Laufs,

Clare OliverWilliams,

Angela Wood,

Adam S. Butterworth,

Emanuele Di Angelantonio,

John Danesh,

Stephen J. Nicholls,

Deepak L. Bhatt,

Marc S. Sabatine,

Alberico L. Catapano

Publication year - 2019

Publication title -

jama

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.688

H-Index - 680

eISSN - 1538-3598

pISSN - 0098-7484

DOI - 10.1001/jama.2018.20045

Subject(s) - medicine , apolipoprotein b , pcsk9 , triglyceride , mendelian randomization , ldl receptor , cardiology , myocardial infarction , endocrinology , odds ratio , lipoprotein , cholesterol , genetic variants , genetics , genotype , gene , biology

Triglycerides and cholesterol are both carried in plasma by apolipoprotein B (ApoB)-containing lipoprotein particles. It is unknown whether lowering plasma triglyceride levels reduces the risk of cardiovascular events to the same extent as lowering low-density lipoprotein cholesterol (LDL-C) levels.

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