Open AccessAssociation of Genetic Variants Related to Gluteofemoral vs Abdominal Fat Distribution With Type 2 Diabetes, Coronary Disease, and Cardiovascular Risk Factors
Author(s) -
Luca A. Lotta,
Laura B. L. Wittemans,
Verena Zuber,
Isobel D. Stewart,
Stephen J. Sharp,
Jian’an Luan,
Felix R. Day,
Chen Li,
Nicholas Bowker,
Lina Cai,
Emanuella De Lucia Rolfe,
KayTee Khaw,
John R. B. Perry,
Stephen O’Rahilly,
Robert A. Scott,
David B. Savage,
Stephen Burgess,
Nicholas J. Wareham,
Claudia Langenberg
Publication year - 2018
Publication title -
jama
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.688
H-Index - 680
eISSN - 1538-3598
pISSN - 0098-7484
DOI - 10.1001/jama.2018.19329
Subject(s) - medicine , genome wide association study , body mass index , waist , waist–hip ratio , cohort , population , type 2 diabetes , diabetes mellitus , endocrinology , single nucleotide polymorphism , genetics , biology , genotype , environmental health , gene
Body fat distribution, usually measured using waist-to-hip ratio (WHR), is an important contributor to cardiometabolic disease independent of body mass index (BMI). Whether mechanisms that increase WHR via lower gluteofemoral (hip) or via higher abdominal (waist) fat distribution affect cardiometabolic risk is unknown.
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