Effect of Inorganic Nitrite vs Placebo on Exercise Capacity Among Patients With Heart Failure With Preserved Ejection Fraction | Zendy

Barry A. Borlaug | Zendy; Kevin J. Anstrom | Zendy; Gregory D. Lewis | Zendy; Sanjiv J. Shah | Zendy; James A. Levine | Zendy; Gabe A. Koepp | Zendy; Michael M. Givertz | Zendy; G. Michael Felker | Zendy; Martin M. LeWinter | Zendy; Douglas L. Mann | Zendy; Kenneth B. Margulies | Zendy; Andrew L. Smith | Zendy; W.H. Wilson Tang | Zendy; David J. Whellan | Zendy; Horng H. Chen | Zendy; Víctor G. DávilaRomán | Zendy; Steven E. McNulty | Zendy; Patrice DesvigneNickens | Zendy; Adrian F. Hernandez | Zendy; Eugene Braunwald | Zendy; Margaret M. Redfield | Zendy

Open Access

Effect of Inorganic Nitrite vs Placebo on Exercise Capacity Among Patients With Heart Failure With Preserved Ejection Fraction

Author(s) -

Barry A. Borlaug,

Kevin J. Anstrom,

Gregory D. Lewis,

Sanjiv J. Shah,

James A. Levine,

Gabe A. Koepp,

Michael M. Givertz,

G. Michael Felker,

Martin M. LeWinter,

Douglas L. Mann,

Kenneth B. Margulies,

Andrew L. Smith,

W.H. Wilson Tang,

David J. Whellan,

Horng H. Chen,

Víctor G. DávilaRomán,

Steven E. McNulty,

Patrice DesvigneNickens,

Adrian F. Hernandez,

Eugene Braunwald,

Margaret M. Redfield

Publication year - 2018

Publication title -

jama

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.688

H-Index - 680

eISSN - 1538-3598

pISSN - 0098-7484

DOI - 10.1001/jama.2018.14852

Subject(s) - medicine , placebo , tolerability , ejection fraction , heart failure , nitrite , crossover study , vo2 max , adverse effect , cardiology , clinical endpoint , brain natriuretic peptide , heart rate , randomized controlled trial , blood pressure , nitrate , alternative medicine , pathology , ecology , biology

There are few effective treatments for heart failure with preserved ejection fraction (HFpEF). Short-term administration of inorganic nitrite or nitrate preparations has been shown to enhance nitric oxide signaling, which may improve aerobic capacity in HFpEF.

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