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Effect of Theophylline as Adjunct to Inhaled Corticosteroids on Exacerbations in Patients With COPD
Author(s) -
Graham Devereux,
Seonaidh Cotton,
Shona Fielding,
Nicola McMeekin,
Peter J. Barnes,
Andrew Briggs,
Graham Burns,
Rekha Chaudhuri,
Henry Chrystyn,
Lisa Davies,
Anthony De Soyza,
Simon Gompertz,
John Haughney,
Karen Innes,
Joanna Kaniewska,
Amanda Lee,
Alyn H. Morice,
John Norrie,
A. Sullivan,
Andrew M. Wilson,
David Price
Publication year - 2018
Publication title -
jama
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.688
H-Index - 680
eISSN - 1538-3598
pISSN - 0098-7484
DOI - 10.1001/jama.2018.14432
Subject(s) - medicine , theophylline , copd , placebo , randomized controlled trial , bronchodilator , corticosteroid , asthma , clinical trial , anesthesia , alternative medicine , pathology
Chronic obstructive pulmonary disease (COPD) is a major global health issue and theophylline is used extensively. Preclinical investigations have demonstrated that low plasma concentrations (1-5 mg/L) of theophylline enhance antiinflammatory effects of corticosteroids in COPD.

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