Effect of Human Recombinant Alkaline Phosphatase on 7-Day Creatinine Clearance in Patients With Sepsis-Associated Acute Kidney Injury | Zendy

Peter Pickkers | Zendy; Ravindra L. Mehta | Zendy; Patrick Murray | Zendy; Michael Joannidis | Zendy; Bruce A. Molitoris | Zendy; John A. Kellum | Zendy; Mirjam Bachler | Zendy; Eric A. J. Hoste | Zendy; Oscar Hoiting | Zendy; Kenneth Krell | Zendy; Marlies Ostermann | Zendy; Wim Rozendaal | Zendy; Miia Valkonen | Zendy; David Brealey | Zendy; Albertus Beishuizen | Zendy; Ferhat Meziani | Zendy; Raghavan Murugan | Zendy; Hilde de Geus | Zendy; Didier Payen | Zendy; Erik van den Berg | Zendy; Jacques Arend | Zendy

Open Access

Effect of Human Recombinant Alkaline Phosphatase on 7-Day Creatinine Clearance in Patients With Sepsis-Associated Acute Kidney Injury

Author(s) -

Peter Pickkers,

Ravindra L. Mehta,

Patrick Murray,

Michael Joannidis,

Bruce A. Molitoris,

John A. Kellum,

Mirjam Bachler,

Eric A. J. Hoste,

Oscar Hoiting,

Kenneth Krell,

Marlies Ostermann,

Wim Rozendaal,

Miia Valkonen,

David Brealey,

Albertus Beishuizen,

Ferhat Meziani,

Raghavan Murugan,

Hilde de Geus,

Didier Payen,

Erik van den Berg,

Jacques Arend

Publication year - 2018

Publication title -

jama

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.688

H-Index - 680

eISSN - 1538-3598

pISSN - 0098-7484

DOI - 10.1001/jama.2018.14283

Subject(s) - medicine , acute kidney injury , sepsis , renal function , placebo , creatinine , alkaline phosphatase , clinical endpoint , adverse effect , urology , randomized controlled trial , intensive care unit , kidney , gastroenterology , pathology , enzyme , biochemistry , chemistry , alternative medicine

Sepsis-associated acute kidney injury (AKI) adversely affects long-term kidney outcomes and survival. Administration of the detoxifying enzyme alkaline phosphatase may improve kidney function and survival.

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