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Association Between Elevated Brain Amyloid and Subsequent Cognitive Decline Among Cognitively Normal Persons
Author(s) -
Michael Donohue,
Reisa A. Sperling,
Ronald C. Petersen,
ChungKai Sun,
Michael W. Weiner,
Paul Aisen
Publication year - 2017
Publication title -
jama
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.688
H-Index - 680
eISSN - 1538-3598
pISSN - 0098-7484
DOI - 10.1001/jama.2017.6669
Subject(s) - medicine , dementia , interquartile range , positron emission tomography , cognitive decline , clinical dementia rating , alzheimer's disease neuroimaging initiative , neuroimaging , cognition , standardized uptake value , amyloid (mycology) , pittsburgh compound b , biomarker , alzheimer's disease , disease , psychiatry , pathology , nuclear medicine , biochemistry , chemistry
Among cognitively normal individuals, elevated brain amyloid (defined by cerebrospinal fluid assays or positron emission tomography regional summaries) can be related to risk for later Alzheimer-related cognitive decline.

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