Association of Rare and Common Variation in the Lipoprotein Lipase Gene With Coronary Artery Disease | Zendy

Amit V. Khera | Zendy; HongHee Won | Zendy; Gina M. Peloso | Zendy; Colm O’Dushlaine | Zendy; Dajiang J. Liu | Zendy; Nathan O. Stitziel | Zendy; Pradeep Natarajan | Zendy; Akihiro Nomura | Zendy; Connor A. Emdin | Zendy; Namrata Gupta | Zendy; Ingrid B. Borecki | Zendy; Rosanna Asselta | Zendy; Stefano Duga | Zendy; Piera Angelica Merlini | Zendy; Adolfo Correa | Zendy; Thorsten Kessler | Zendy; James G. Wilson | Zendy; Matthew J. Bown | Zendy; Alistair S. Hall | Zendy; Peter S. Braund | Zendy; David J. Carey | Zendy; Michael F. Murray | Zendy; H. Lester Kirchner | Zendy; Joseph B. Leader | Zendy; Daniel R. Lavage | Zendy; J. Neil Manus | Zendy; Dustin N. Hartzel | Zendy; Nilesh J. Samani | Zendy; Heribert Schunkert | Zendy; Jaume Marrugat | Zendy; Roberto Elosúa | Zendy; Ruth McPherson | Zendy; Martin Farrall | Zendy; Hugh Watkins | Zendy; Eric S. Lander | Zendy; Daniel J. Rader | Zendy; John Danesh | Zendy; Diego Ardissino | Zendy; Stacey Gabriel | Zendy; Cristen J. Willer | Zendy; Gonçalo R. Abecasis | Zendy; Danish Saleheen | Zendy; Frederick E. Dewey | Zendy; Sekar Kathiresan | Zendy

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Association of Rare and Common Variation in the Lipoprotein Lipase Gene With Coronary Artery Disease

Author(s) -

Amit V. Khera,

HongHee Won,

Gina M. Peloso,

Colm O’Dushlaine,

Dajiang J. Liu,

Nathan O. Stitziel,

Pradeep Natarajan,

Akihiro Nomura,

Connor A. Emdin,

Namrata Gupta,

Ingrid B. Borecki,

Rosanna Asselta,

Stefano Duga,

Piera Angelica Merlini,

Adolfo Correa,

Thorsten Kessler,

James G. Wilson,

Matthew J. Bown,

Alistair S. Hall,

Peter S. Braund,

David J. Carey,

Michael F. Murray,

H. Lester Kirchner,

Joseph B. Leader,

Daniel R. Lavage,

J. Neil Manus,

Dustin N. Hartzel,

Nilesh J. Samani,

Heribert Schunkert,

Jaume Marrugat,

Roberto Elosúa,

Ruth McPherson,

Martin Farrall,

Hugh Watkins,

Eric S. Lander,

Daniel J. Rader,

John Danesh,

Diego Ardissino,

Stacey Gabriel,

Cristen J. Willer,

Gonçalo R. Abecasis,

Danish Saleheen,

Frederick E. Dewey,

Sekar Kathiresan

Publication year - 2017

Publication title -

jama

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.688

H-Index - 680

eISSN - 1538-3598

pISSN - 0098-7484

DOI - 10.1001/jama.2017.0972

Subject(s) - medicine , lipoprotein lipase , coronary artery disease , missense mutation , case control study , genetics , myocardial infarction , bioinformatics , endocrinology , mutation , gene , biology , adipose tissue

The activity of lipoprotein lipase (LPL) is the rate-determining step in clearing triglyceride-rich lipoproteins from the circulation. Mutations that damage the LPL gene (LPL) lead to lifelong deficiency in enzymatic activity and can provide insight into the relationship of LPL to human disease.

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