Effect of Deutetrabenazine on Chorea Among Patients With Huntington Disease
Author(s) -
Samuel Frank,
Claudia Testa,
David Stamler,
Elise Kayson,
Charles S. Davis,
Mary Edmondson,
Shari Kinel,
Blair R. Leavitt,
David Oakes,
Christine J. O’Neill,
Christina Vaughan,
Jody Goldstein,
Margaret Herzog,
Victoria Snively,
Jacquelyn Whaley,
Cynthia Wong,
Greg Suter,
Joseph Jankovic,
Joohi JimenezShahed,
Christine Hunter,
Daniel O. Claassen,
Olivia C. Roman,
Victor Sung,
Jenna Smith,
Sarah Janicki,
Ronda Clouse,
Marie SaintHilaire,
Anna DePold Hohler,
Denyse Turpin,
Raymond James,
Ramon L. Rodriguez,
Kyle Rizer,
Karen E. Anderson,
Hope Heller,
Alexis Carlson,
Susan R. Criswell,
Brad A. Racette,
Fredy J. Revilla,
Frederick C. Nucifora,
Russell L. Margolis,
MaryJane Ong,
Tilak Mendis,
Neila Mendis,
Carlos Singer,
Mónica Quesada,
Jane S. Paulsen,
Thomas Brashers-Krug,
Amanda C. Miller,
Jane Kerr,
Richard Dubinsky,
Carolyn Steele Gray,
Stewart A. Factor,
Elaine Sperin,
Eric Molho,
Mary Eglow,
Sharon Evans,
Rajeev Kumar,
Christina Reeves,
Ali Samii,
Sylvain Chouinard,
Monica Beland,
B.L. Scott,
Patrick Hickey,
Sherali Esmail,
Wai Lun Alan Fung,
Clare Gibbons,
Lina Qi,
Amy Colcher,
Cory Hackmyer,
Andrew McGarry,
Kevin J. Klos,
Mark Gudesblatt,
Lori Fafard,
Laura Graffitti,
Daniel Schneider,
Rohit Dhall,
Joanne Wojcieszek,
Kathrin LaFaver,
Andrew P. Duker,
Erin Neefus,
Hilary Wilson,
David Shprecher,
Paola Wall,
Karen Blindauer,
Lynn Wheeler,
James T. Boyd,
Emily Houston,
Eric S. Farbman,
Pinky Agarwal,
Shirley Eberly,
Arthur Watts,
Pierre N. Tariot,
Andrew Feigin,
Scott Evans,
Chris Beck,
Constance Orme,
Jon Edicola,
Emily Christopher
Publication year - 2016
Publication title -
jama
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.688
H-Index - 680
eISSN - 1538-3598
pISSN - 0098-7484
DOI - 10.1001/jama.2016.8655
Subject(s) - medicine , chorea , placebo , clinical global impression , ambulatory , huntington's disease , randomized controlled trial , disease , physical therapy , pediatrics , alternative medicine , pathology
Deutetrabenazine is a novel molecule containing deuterium, which attenuates CYP2D6 metabolism and increases active metabolite half-lives and may therefore lead to stable systemic exposure while preserving key pharmacological activity.
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