Effect of Losmapimod on Cardiovascular Outcomes in Patients Hospitalized With Acute Myocardial Infarction | Zendy

Michelle L. O’Donoghue | Zendy; Ruchira Glaser | Zendy; Matthew A. Cavender | Zendy; Philip E. Aylward | Zendy; Marc P. Bonaca | Zendy; Andrzej Budaj | Zendy; Richard Y. Davies | Zendy; Mikael Dellborg | Zendy; Keith A.A. Fox | Zendy; J. Antonio Gutierrez | Zendy; Christian W. Hamm | Zendy; Róbert Gábor Kiss | Zendy; František Kovář | Zendy; Julia Kuder | Zendy; Kyung Ah Im | Zendy; John J. Lepore | Zendy; José L. López-Sendón | Zendy; Ton Oude Ophuis | Zendy; Alexander Parkhomenko | Zendy; Jennifer B. Shan | Zendy; Jindřich Špinar | Zendy; Jean-François Tanguay | Zendy; Mikhail Ruda | Zendy; Philippe Gabríel Steg | Zendy; Pierre Théroux | Zendy; Stephen D. Wiviott | Zendy; Ian Laws | Zendy; Marc S. Sabatine | Zendy; David A. Morrow | Zendy

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Effect of Losmapimod on Cardiovascular Outcomes in Patients Hospitalized With Acute Myocardial Infarction

Author(s) -

Michelle L. O’Donoghue,

Ruchira Glaser,

Matthew A. Cavender,

Philip E. Aylward,

Marc P. Bonaca,

Andrzej Budaj,

Richard Y. Davies,

Mikael Dellborg,

Keith A.A. Fox,

J. Antonio Gutierrez,

Christian W. Hamm,

Róbert Gábor Kiss,

František Kovář,

Julia Kuder,

Kyung Ah Im,

John J. Lepore,

José L. López-Sendón,

Ton Oude Ophuis,

Alexander Parkhomenko,

Jennifer B. Shan,

Jindřich Špinar,

Jean-François Tanguay,

Mikhail Ruda,

Philippe Gabríel Steg,

Pierre Théroux,

Stephen D. Wiviott,

Ian Laws,

Marc S. Sabatine,

David A. Morrow

Publication year - 2016

Publication title -

jama

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.688

H-Index - 680

eISSN - 1538-3598

pISSN - 0098-7484

DOI - 10.1001/jama.2016.3609

Subject(s) - medicine , myocardial infarction , timi , clinical endpoint , placebo , randomized controlled trial , cardiology , revascularization , intention to treat analysis , percutaneous coronary intervention , pathology , alternative medicine

p38 Mitogen-activated protein kinase (MAPK)-stimulated inflammation is implicated in atherogenesis, plaque destabilization, and maladaptive processes in myocardial infarction (MI). Pilot data in a phase 2 trial in non-ST elevation MI indicated that the p38 MAPK inhibitor losmapimod attenuates inflammation and may improve outcomes.

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