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Effect of a Proposed Trastuzumab Biosimilar Compared With Trastuzumab on Overall Response Rate in Patients With ERBB2 (HER2)–Positive Metastatic Breast Cancer
Author(s) -
Hope S. Rugo,
Abhijit Barve,
Cornelius F. Waller,
M. Hernández-Bronchud,
Jay Herson,
Jinyu Yuan,
Rajiv Sharma,
Mark Baczkowski,
Mudgal Kothekar,
Subramanian Loganathan,
Alexey Manikhas,
Igor Bondarenko,
Guzel Mukhametshina,
Gia Nemsadze,
Joseph D. Parra,
Maria Luisa T. Abesamis-Tiambeng,
Kakhaber Baramidze,
Charuwan Akewanlop,
Ihor Vynnychenko,
Virote Sriuranpong,
Gopichand Mamillapalli,
Sirshendu Ray,
Eduardo Patricio Yanez Ruiz,
Eduardo J. Pennella,
for the Heritage Study Investigators
Publication year - 2016
Publication title -
jama
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.688
H-Index - 680
eISSN - 1538-3598
pISSN - 0098-7484
DOI - 10.1001/jama.2016.18305
Subject(s) - trastuzumab , medicine , taxane , biosimilar , metastatic breast cancer , oncology , breast cancer , population , cancer , environmental health
Treatment with the anti-ERBB2 humanized monoclonal antibody trastuzumab and chemotherapy significantly improves outcome in patients with ERBB2 (HER2)-positive metastatic breast cancer; a clinically effective biosimilar may help increase access to this therapy.

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