Association Between Low-Density Lipoprotein Cholesterol–Lowering Genetic Variants and Risk of Type 2 Diabetes | Zendy

Luca A. Lotta | Zendy; Stephen J. Sharp | Zendy; Stephen Burgess | Zendy; John R. B. Perry | Zendy; Isobel D. Stewart | Zendy; Sara M. Willems | Zendy; Jian’an Luan | Zendy; Eva Ardanáz | Zendy; Larraitz Arriola | Zendy; Beverley Balkau | Zendy; Heiner Boeing | Zendy; Panos Deloukas | Zendy; Nita G. Forouhi | Zendy; Paul W. Franks | Zendy; Sara Grioni | Zendy; Rudolf Kaaks | Zendy; Timothy J. Key | Zendy; Carmen Navarro | Zendy; Peter M. Nilsson | Zendy; Kim Overvad | Zendy; Domenico Palli | Zendy; Salvatore Panico | Zendy; Jose-Ramón Quirós | Zendy; Elio Ríboli | Zendy; Olov Rolandsson | Zendy; Carlotta Sacerdote | Zendy; Elena SalamancaFernández | Zendy; Nadia Slimani | Zendy; Annemieke M. W. Spijkerman | Zendy; Anne Tjønneland | Zendy; ­Rosario ­Tumino | Zendy; Daphne L. van der A | Zendy; Yvonne T. van der Schouw | Zendy; Mark I. McCarthy | Zendy; Inês Barroso | Zendy; Stephen O’Rahilly | Zendy; David B. Savage | Zendy; Naveed Sattar | Zendy; Claudia Langenberg | Zendy; Robert A. Scott | Zendy; Nicholas J. Wareham | Zendy

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Association Between Low-Density Lipoprotein Cholesterol–Lowering Genetic Variants and Risk of Type 2 Diabetes

Author(s) -

Luca A. Lotta,

Stephen J. Sharp,

Stephen Burgess,

John R. B. Perry,

Isobel D. Stewart,

Sara M. Willems,

Jian’an Luan,

Eva Ardanáz,

Larraitz Arriola,

Beverley Balkau,

Heiner Boeing,

Panos Deloukas,

Nita G. Forouhi,

Paul W. Franks,

Sara Grioni,

Rudolf Kaaks,

Timothy J. Key,

Carmen Navarro,

Peter M. Nilsson,

Kim Overvad,

Domenico Palli,

Salvatore Panico,

Jose-Ramón Quirós,

Elio Ríboli,

Olov Rolandsson,

Carlotta Sacerdote,

Elena SalamancaFernández,

Nadia Slimani,

Annemieke M. W. Spijkerman,

Anne Tjønneland,

Rosario Tumino,

Daphne L. van der A,

Yvonne T. van der Schouw,

Mark I. McCarthy,

Inês Barroso,

Stephen O’Rahilly,

David B. Savage,

Naveed Sattar,

Claudia Langenberg,

Robert A. Scott,

Nicholas J. Wareham

Publication year - 2016

Publication title -

jama

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.688

H-Index - 680

eISSN - 1538-3598

pISSN - 0098-7484

DOI - 10.1001/jama.2016.14568

Subject(s) - medicine , ezetimibe , pcsk9 , type 2 diabetes , diabetes mellitus , odds ratio , coronary artery disease , allele , ldl receptor , endocrinology , statin , cholesterol , lipoprotein , bioinformatics , genetics , gene , biology

Low-density lipoprotein cholesterol (LDL-C)-lowering alleles in or near NPC1L1 or HMGCR, encoding the respective molecular targets of ezetimibe and statins, have previously been used as proxies to study the efficacy of these lipid-lowering drugs. Alleles near HMGCR are associated with a higher risk of type 2 diabetes, similar to the increased incidence of new-onset diabetes associated with statin treatment in randomized clinical trials. It is unknown whether alleles near NPC1L1 are associated with the risk of type 2 diabetes.

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