Effect of Corticosteroids on Treatment Failure Among Hospitalized Patients With Severe Community-Acquired Pneumonia and High Inflammatory Response | Zendy

Antoní Torres | Zendy; Oriol Sibila | Zendy; Miquel Ferrer | Zendy; Eva Polverino | Zendy; Rosario Menéndez | Zendy; Josep Mensa | Zendy; Albert Gabarrús | Zendy; Jacobo Sellarés | Zendy; Marcos I. Restrepo | Zendy; Antonio Anzueto | Zendy; Michael S. Niederman | Zendy; Carles Agustı́ | Zendy

Open Access

Effect of Corticosteroids on Treatment Failure Among Hospitalized Patients With Severe Community-Acquired Pneumonia and High Inflammatory Response

Author(s) -

Antoní Torres,

Oriol Sibila,

Miquel Ferrer,

Eva Polverino,

Rosario Menéndez,

Josep Mensa,

Albert Gabarrús,

Jacobo Sellarés,

Marcos I. Restrepo,

Antonio Anzueto,

Michael S. Niederman,

Carles Agustı́

Publication year - 2015

Publication title -

jama

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.688

H-Index - 680

eISSN - 1538-3598

pISSN - 0098-7484

DOI - 10.1001/jama.2015.88

Subject(s) - medicine , methylprednisolone , pneumonia , community acquired pneumonia , mechanical ventilation , respiratory failure , placebo , randomized controlled trial , clinical trial , septic shock , sepsis , alternative medicine , pathology

In patients with severe community-acquired pneumonia, treatment failure is associated with excessive inflammatory response and worse outcomes. Corticosteroids may modulate cytokine release in these patients, but the benefit of this adjunctive therapy remains controversial.

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