Efavirenz-Based Antiretroviral Therapy Among Nevirapine-Exposed HIV-Infected Children in South Africa | Zendy

Ashraf Coovadia | Zendy; Elaine J. Abrams | Zendy; Renate Strehlau | Zendy; Stephanie Shiau | Zendy; Francoise Pinillos | Zendy; Leigh Martens | Zendy; Faeezah Patel | Zendy; Gillian Hunt | Zendy; WeiYann Tsai | Zendy; Louise Kuhn | Zendy

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Efavirenz-Based Antiretroviral Therapy Among Nevirapine-Exposed HIV-Infected Children in South Africa

Author(s) -

Ashraf Coovadia,

Elaine J. Abrams,

Renate Strehlau,

Stephanie Shiau,

Francoise Pinillos,

Leigh Martens,

Faeezah Patel,

Gillian Hunt,

WeiYann Tsai,

Louise Kuhn

Publication year - 2015

Publication title -

jama

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.688

H-Index - 680

eISSN - 1538-3598

pISSN - 0098-7484

DOI - 10.1001/jama.2015.13631

Subject(s) - nevirapine , efavirenz , medicine , lopinavir , ritonavir , viral load , lopinavir/ritonavir , pediatrics , virology , human immunodeficiency virus (hiv) , antiretroviral therapy

Advantages of using efavirenz as part of treatment for children infected with human immunodeficiency virus (HIV) include once-daily dosing, simplification of co-treatment for tuberculosis, preservation of ritonavir-boosted lopinavir for second-line treatment, and harmonization of adult and pediatric treatment regimens. However, there have been concerns about possible reduced viral efficacy of efavirenz in children exposed to nevirapine for prevention of mother-to-child transmission.

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