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Out-of-Hospital Administration of Intravenous Glucose-Insulin-Potassium in Patients With Suspected Acute Coronary Syndromes
Author(s) -
Harry P. Selker,
Joni R. Beshansky,
Patricia Sheehan,
Joseph M. Massaro,
John L. Griffith,
Ralph B. D’Agostino,
Robin Ruthazer,
James M. Atkins,
Assaad Sayah,
Michael Levy,
Michael Richards,
Tom P. Aufderheide,
Darren Braude,
Ronald G. Pirrallo,
Delanor D. Doyle,
Ralph J. Frascone,
Donald J. Kosiak,
James M. Leaming,
Carin M. Van Gelder,
Gert Paul Walter,
Marvin A. Wayne,
Robert Woolard,
Lionel H. Opie,
Charles E. Rackley,
Carl S. Apstein,
James E. Udelson
Publication year - 2012
Publication title -
jama
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.688
H-Index - 680
eISSN - 1538-3598
pISSN - 0098-7484
DOI - 10.1001/jama.2012.426
Subject(s) - medicine , myocardial infarction , placebo , hazard ratio , randomized controlled trial , clinical endpoint , emergency medical services , emergency department , odds ratio , acute coronary syndrome , emergency medicine , anesthesia , cardiology , confidence interval , alternative medicine , pathology , psychiatry
Laboratory studies suggest that in the setting of cardiac ischemia, immediate intravenous glucose-insulin-potassium (GIK) reduces ischemia-related arrhythmias and myocardial injury. Clinical trials have not consistently shown these benefits, possibly due to delayed administration.

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