Association Between Treatment With Brachytherapy vs Whole-Breast Irradiation and Subsequent Mastectomy, Complications, and Survival Among Older Women With Invasive Breast Cancer | Zendy

Grace L. Smith | Zendy; Ying Xu | Zendy; Thomas A. Buchholz | Zendy; Sharon H. Giordano | Zendy; Jing Jiang | Zendy; YaChen Tina Shih | Zendy; Benjamin D. Smith | Zendy

Open Access

Association Between Treatment With Brachytherapy vs Whole-Breast Irradiation and Subsequent Mastectomy, Complications, and Survival Among Older Women With Invasive Breast Cancer

Author(s) -

Grace L. Smith,

Ying Xu,

Thomas A. Buchholz,

Sharon H. Giordano,

Jing Jiang,

YaChen Tina Shih,

Benjamin D. Smith

Publication year - 2012

Publication title -

jama

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.688

H-Index - 680

eISSN - 1538-3598

pISSN - 0098-7484

DOI - 10.1001/jama.2012.3481

Subject(s) - medicine , brachytherapy , lumpectomy , breast cancer , cumulative incidence , mastectomy , hazard ratio , proportional hazards model , population , cohort , randomized controlled trial , radiation therapy , odds ratio , incidence (geometry) , oncology , cancer , gynecology , confidence interval , physics , environmental health , optics

Brachytherapy is a radiation treatment that uses an implanted radioactive source. In recent years, use of breast brachytherapy after lumpectomy for early breast cancer has increased substantially despite a lack of randomized trial data comparing its effectiveness with standard whole-breast irradiation (WBI). Because results of long-term randomized trials will not be reported for years, detailed analysis of clinical outcomes in a nonrandomized setting is warranted.

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