Genetic Variants and Associations of 25-Hydroxyvitamin D Concentrations With Major Clinical Outcomes | Zendy

Gregory P. Levin | Zendy; Cassianne RobinsonCohen | Zendy; Ian H. de Boer | Zendy; Denise K. Houston | Zendy; Kurt Lohman | Zendy; Yongmei Liu | Zendy; Stephen B. Kritchevsky | Zendy; Jane A. Cauley | Zendy; Toshiko Tanaka | Zendy; Luigi Ferrucci | Zendy; Stefania Bandinelli | Zendy; Kushang V. Patel | Zendy; Emil Hagström | Zendy; Karl Michaëlsson | Zendy; Håkan Melhus | Zendy; Thomas J. Wang | Zendy; Myles Wolf | Zendy; Bruce M. Psaty | Zendy; David S. Siscovick | Zendy; Bryan Kestenbaum | Zendy

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Genetic Variants and Associations of 25-Hydroxyvitamin D Concentrations With Major Clinical Outcomes

Author(s) -

Gregory P. Levin,

Cassianne RobinsonCohen,

Ian H. de Boer,

Denise K. Houston,

Kurt Lohman,

Yongmei Liu,

Stephen B. Kritchevsky,

Jane A. Cauley,

Toshiko Tanaka,

Luigi Ferrucci,

Stefania Bandinelli,

Kushang V. Patel,

Emil Hagström,

Karl Michaëlsson,

Håkan Melhus,

Thomas J. Wang,

Myles Wolf,

Bruce M. Psaty,

David S. Siscovick,

Bryan Kestenbaum

Publication year - 2012

Publication title -

jama

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.688

H-Index - 680

eISSN - 1538-3598

pISSN - 0098-7484

DOI - 10.1001/jama.2012.17304

Subject(s) - medicine , vitamin d and neurology , context (archaeology) , calcitriol receptor , vitamin d binding protein , prospective cohort study , cohort study , vitamin d deficiency , cohort , endocrinology , biology , paleontology

Lower serum 25-hydroxyvitamin D concentrations are associated with greater risks of many chronic diseases across large, prospective community-based studies. Substrate 25-hydroxyvitamin D must be converted to 1,25-dihydroxyvitamin D for full biological activity, and complex metabolic pathways suggest that interindividual variability in vitamin D metabolism may alter the clinical consequences of measured serum 25-hydroxyvitamin D.

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