Association Between Use of Renin-Angiotensin System Antagonists and Mortality in Patients With Heart Failure and Preserved Ejection Fraction | Zendy

Lars H. Lund | Zendy; Lina Benson | Zendy; Ulf Dahlström | Zendy; Magnus Edner | Zendy

Open Access

Association Between Use of Renin-Angiotensin System Antagonists and Mortality in Patients With Heart Failure and Preserved Ejection Fraction

Author(s) -

Lars H. Lund,

Lina Benson,

Ulf Dahlström,

Magnus Edner

Publication year - 2012

Publication title -

jama

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.688

H-Index - 680

eISSN - 1538-3598

pISSN - 0098-7484

DOI - 10.1001/jama.2012.14785

Subject(s) - medicine , heart failure , ejection fraction , heart failure with preserved ejection fraction , propensity score matching , cardiology , cohort

Heart failure with preserved ejection fraction (HFPEF) may be as common and as lethal as heart failure with reduced ejection fraction (HFREF). Three randomized trials of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers (ie, renin-angiotensin system [RAS] antagonists) did not reach primary end points but may have had selection bias or been underpowered.

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