Open AccessFunctional Variants of the <emph type="ital">HMGA1</emph> Gene and Type 2 Diabetes Mellitus
Author(s) -
Eusebio Chiefari
Publication year - 2011
Publication title -
jama
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.688
H-Index - 680
eISSN - 1538-3598
pISSN - 0098-7484
DOI - 10.1001/jama.2011.207
Subject(s) - medicine , type 2 diabetes , type 2 diabetes mellitus , odds ratio , single nucleotide polymorphism , endocrinology , diabetes mellitus , gene , genetics , genotype , biology
High-mobility group A1 (HMGA1) protein is a key regulator of insulin receptor (INSR) gene expression. We previously identified a functional HMGA1 gene variant in 2 insulin-resistant patients with decreased INSR expression and type 2 diabetes mellitus (DM).
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom