Open AccessTelomere Length and Risk of Incident Cancer and Cancer Mortality
Author(s) -
Peter Willeit,
Johann Willeit,
Agnes Mayr,
Siegfried Weger,
Friedrich Oberhollenzer,
Anita KlossBrandstätter,
Florian Kronenberg,
Stefan Kiechl
Publication year - 2010
Publication title -
jama
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.688
H-Index - 680
eISSN - 1538-3598
pISSN - 0098-7484
DOI - 10.1001/jama.2010.897
Subject(s) - medicine , telomere , cancer , hazard ratio , incidence (geometry) , confidence interval , population , prospective cohort study , oncology , genetics , biology , environmental health , dna , physics , optics
Telomeres are essential to preserve the integrity of the genome. Critically short telomeres lead to replicative cell senescence and chromosomal instability and may thereby increase cancer risk.
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