Open AccessA Network Model of a Cooperative Genetic Landscape in Brain Tumors
Author(s) -
Markus Bredel,
Denise Scholtens,
Griffith R. Harsh,
Claudia Bredel,
James P. Chandler,
Jaclyn J. Renfrow,
Ajay K. Yadav,
Hannes Vogel,
Adrienne C. Scheck,
Robert Tibshirani,
Branimir I. Šikić
Publication year - 2009
Publication title -
jama
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.688
H-Index - 680
eISSN - 1538-3598
pISSN - 0098-7484
DOI - 10.1001/jama.2009.997
Subject(s) - medicine , computational biology , neuroscience , biology
Gliomas, particularly glioblastomas, are among the deadliest of human tumors. Gliomas emerge through the accumulation of recurrent chromosomal alterations, some of which target yet-to-be-discovered cancer genes. A persistent question concerns the biological basis for the coselection of these alterations during gliomagenesis.
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