Altitude and All-Cause Mortality in Incident Dialysis Patients | Zendy

Wolfgang C. Winkelmayer­ | Zendy; Jun Liu | Zendy; M. Alan Brookhart | Zendy

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Altitude and All-Cause Mortality in Incident Dialysis Patients

Author(s) -

Wolfgang C. Winkelmayer,

Jun Liu,

M. Alan Brookhart

Publication year - 2009

Publication title -

jama

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.688

H-Index - 680

eISSN - 1538-3598

pISSN - 0098-7484

DOI - 10.1001/jama.2009.84

Subject(s) - medicine , dialysis , population , proportional hazards model , mortality rate , altitude (triangle) , retrospective cohort study , cohort , hypoxia (environmental) , demography , surgery , pediatrics , environmental health , chemistry , geometry , mathematics , organic chemistry , sociology , oxygen

Patients undergoing dialysis at higher altitude receive lower erythropoietin doses, yet achieve higher hemoglobin concentrations. Increased iron availability caused by activation of hypoxia-induced factors at higher altitude may explain this finding. Hypoxia-induced factors are also involved in other pathways that may affect morbidity and mortality.

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