Hypertonic Resuscitation of Hypovolemic Shock After Blunt Trauma | Zendy

Eileen M. Bulger | Zendy; Gregory J. Jurkovich | Zendy; Avery B. Nathens | Zendy; Michael K. Copass | Zendy; Sandy Hanson | Zendy; C. Cooper | Zendy; Ping Yu Liu | Zendy; Margaret J. Neff | Zendy; Asaad B. Awan | Zendy; Keir J. Warner | Zendy; Ronald V. Maier | Zendy

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Hypertonic Resuscitation of Hypovolemic Shock After Blunt Trauma

Author(s) -

Eileen M. Bulger,

Gregory J. Jurkovich,

Avery B. Nathens,

Michael K. Copass,

Sandy Hanson,

C. Cooper,

Ping Yu Liu,

Margaret J. Neff,

Asaad B. Awan,

Keir J. Warner,

Ronald V. Maier

Publication year - 2008

Publication title -

archives of surgery

Language(s) - English

Resource type - Journals

eISSN - 1538-3644

pISSN - 0004-0010

DOI - 10.1001/archsurg.2007.41

Subject(s) - medicine , ards , resuscitation , blunt trauma , injury severity score , population , hypertonic saline , anesthesia , trauma center , shock (circulatory) , surgery , poison control , retrospective cohort study , emergency medicine , injury prevention , lung , environmental health

The leading cause of late mortality after trauma is multiple organ failure syndrome, due to a dysfunctional inflammatory response early after injury. Preclinical studies demonstrate that hypertonicity alters the activation of inflammatory cells, leading to reduction in organ injury. The purpose of this study was to evaluate the effect of hypertonicity on organ injury after blunt trauma.

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