Open AccessPhysiological Levels of 5α-Dihydrotestosterone Depress Wound Immune Function and Impair Wound Healing Following Trauma-Hemorrhage
Author(s) -
S. Nitsch,
F Wittmann,
Peter Angele,
Matthias W. Wichmann,
Rudolf Hatz,
T. Hernández-Richter,
Irshad H. Chaudry,
Karl Walter Jauch,
Martin K. Angele
Publication year - 2004
Publication title -
archives of surgery
Language(s) - English
Resource type - Journals
eISSN - 1538-3644
pISSN - 0004-0010
DOI - 10.1001/archsurg.139.2.157
Subject(s) - medicine , wound healing , immune system , lipopolysaccharide , dihydrotestosterone , inflammation , endocrinology , androgen , surgery , hormone , immunology
Studies indicate that a depressed wound immune function contributes to an increased rate of wound complications and impaired wound healing following trauma-hemorrhage (T-H). Androgen, ie, 5 alpha-dihydrotestosterone, is responsible for producing the depressed systemic cell-mediated immune responses following T-H in males. The aim of the present study was to determine whether depletion of 5 alpha-dihydrotestosterone in males before T-H has any salutary effects on wound immune cell function and wound healing in male mice following T-H.