Open AccessNuclear Factor–κB Is Activated in Intestinal Mucosa During Endotoxemia
Author(s) -
Timothy A. Pritts,
Minho Moon,
Josef E. Fischer,
Andrew L. Salzman,
Per-Olof Hasselgren
Publication year - 1998
Publication title -
archives of surgery
Language(s) - English
Resource type - Journals
eISSN - 1538-3644
pISSN - 0004-0010
DOI - 10.1001/archsurg.133.12.1311
Subject(s) - lipopolysaccharide , intestinal mucosa , western blot , blot , medicine , electrophoretic mobility shift assay , sepsis , p50 , microbiology and biotechnology , pathology , endocrinology , immunology , biology , gene expression , transcription factor , biochemistry , gene
The transcription factor nuclear factor-kappaB (NF-kappaB) regulates a large number of genes involved in the inflammatory response to critical illness. The intestinal mucosa plays an active role in the inflammatory and metabolic response to sepsis and endotoxemia, but it is not known if NF-kappaB is activated in the mucosa during these conditions.