Alternative Splicing, Methylation State, and Expression Profile of Tropomyosin-Related Kinase B in the Frontal Cortex of Suicide Completers | Zendy

Carl Ernst | Zendy; Vesselina Deleva | Zendy; Xiaoming Deng | Zendy; Adolfo Sequeira | Zendy; Amanda Pomarenski | Zendy; Tim Klempan | Zendy; Neil A. Ernst | Zendy; Rémi Quirion | Zendy; Alain Gratton | Zendy; Moshe Szyf | Zendy; Gustavo Turecki | Zendy

Open Access

Alternative Splicing, Methylation State, and Expression Profile of Tropomyosin-Related Kinase B in the Frontal Cortex of Suicide Completers

Author(s) -

Carl Ernst,

Vesselina Deleva,

Xiaoming Deng,

Adolfo Sequeira,

Amanda Pomarenski,

Tim Klempan,

Neil A. Ernst,

Rémi Quirion,

Alain Gratton,

Moshe Szyf,

Gustavo Turecki

Publication year - 2009

Publication title -

archives of general psychiatry

Language(s) - English

Resource type - Journals

eISSN - 1538-3636

pISSN - 0003-990X

DOI - 10.1001/archpsyc.66.1.22

Subject(s) - tropomyosin receptor kinase b , epigenetics , tropomyosin , microarray , neuroscience , biology , psychology , neurotrophic factors , medicine , genetics , gene expression , receptor , gene , actin

Although most of the effort to understand the neurobiology of depressive states and suicide has focused on neuronal processes, recent studies suggest that astroglial dysfunction may play an important role. A truncated variant of the tropomyosin-related kinase B (TrkB.T1) is expressed in astrocytes, and brain-derived neurotrophic factor-TrkB signaling has been linked to mood disorders.

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