Seasonal Variation in Human Brain Serotonin Transporter Binding | Zendy

N. Praschak-Rieder | Zendy; Matthäus Willeit | Zendy; Alan A. Wilson | Zendy; Sylvain Houle | Zendy; Jeffrey H. Meyer | Zendy

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Seasonal Variation in Human Brain Serotonin Transporter Binding

Author(s) -

N. Praschak-Rieder,

Matthäus Willeit,

Alan A. Wilson,

Sylvain Houle,

Jeffrey H. Meyer

Publication year - 2008

Publication title -

archives of general psychiatry

Language(s) - English

Resource type - Journals

eISSN - 1538-3636

pISSN - 0003-990X

DOI - 10.1001/archpsyc.65.9.1072

Subject(s) - serotonin transporter , serotonin , binding potential , transporter , serotonin plasma membrane transport proteins , endocrinology , medicine , biology , psychology , biochemistry , receptor , gene

It is a common experience in temperate zones that individuals feel happier and more energetic on bright and sunny days and many experience a decline in mood and energy during the dark winter season. Brain serotonin is involved in the regulation of physiologic functions, such as mating, feeding, energy balance, and sleep. Although these behaviors and serotonin-related conditions show a clear seasonal pattern in humans, the molecular background of seasonal changes in serotonin function is entirely unknown. The serotonin transporter is a key element in regulating intensity and spread of the serotonin signal.

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