Open AccessAn Evaluation of μ-Opioid Receptor (OPRM1) as a Predictor of Naltrexone Response in the Treatment of Alcohol Dependence
Author(s) -
Raymond F. Anton,
Gábor Oroszi,
Stephanie S. O’Malley,
David J. Couper,
Robert M. Swift,
Helen M. Pettinati,
David Goldman
Publication year - 2008
Publication title -
archives of general psychiatry
Language(s) - English
Resource type - Journals
eISSN - 1538-3636
pISSN - 0003-990X
DOI - 10.1001/archpsyc.65.2.135
Subject(s) - naltrexone , placebo , alcohol dependence , medicine , odds ratio , opioid , confidence interval , genotype , pharmacogenetics , alcohol use disorder , allele , psychology , alcohol , pharmacology , receptor , biology , genetics , gene , pathology , biochemistry , alternative medicine
Naltrexone hydrochloride treatment for alcohol dependence works for some individuals but not for everyone. Asn40Asp, a functional polymorphism of the mu-opioid receptor gene (OPRM1), might predict naltrexone response.