Association Between a Functional Serotonin Transporter Promoter Polymorphism and Citalopram Treatment in Adult Outpatients With Major Depression | Zendy

XianZhang Hu | Zendy; A. John Rush | Zendy; Dennis S. Charney | Zendy; Alexander F. Wilson | Zendy; Alexa J.M. Sorant | Zendy; George Papanicolaou | Zendy; Maurizio Fava | Zendy; Madhukar H. Trivedi | Zendy; Stephen R. Wisniewski | Zendy; Gonzalo Laje | Zendy; Silvia Paddock | Zendy; Francis J. McMahon | Zendy; Husseini K. Manji | Zendy; Robert H. Lipsky | Zendy

Open Access

Association Between a Functional Serotonin Transporter Promoter Polymorphism and Citalopram Treatment in Adult Outpatients With Major Depression

Author(s) -

XianZhang Hu,

A. John Rush,

Dennis S. Charney,

Alexander F. Wilson,

Alexa J.M. Sorant,

George Papanicolaou,

Maurizio Fava,

Madhukar H. Trivedi,

Stephen R. Wisniewski,

Gonzalo Laje,

Silvia Paddock,

Francis J. McMahon,

Husseini K. Manji,

Robert H. Lipsky

Publication year - 2007

Publication title -

archives of general psychiatry

Language(s) - English

Resource type - Journals

eISSN - 1538-3636

pISSN - 0003-990X

DOI - 10.1001/archpsyc.64.7.783

Subject(s) - citalopram , serotonin transporter , allele , 5 httlpr , antidepressant , medicine , genotype , major depressive disorder , allele frequency , adverse effect , psychiatry , psychology , oncology , genetics , biology , gene , anxiety , amygdala

The HTTLPR, a functional polymorphism of the serotonin transporter gene solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 (SLC6A4), promoter, affects transcription and may be involved in antidepressant drug treatment outcome, although response rates with antidepressants can be lower in patients who experience adverse effects.

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