A Genetic Family-Based Association Study of OLIG2 in Obsessive-compulsive Disorder | Zendy

S. Evelyn Stewart | Zendy; Jill Platko | Zendy; Jesen Fagerness | Zendy; Julie Birns | Zendy; Eric Jenike | Zendy; Jordan W. Smoller | Zendy; Roy H. Perlis | Zendy; Marion Leboyer | Zendy; Richard Delorme | Zendy; Nadia Chabane | Zendy; Scott L. Rauch | Zendy; Michael A. Jenike | Zendy; David L. Pauls | Zendy

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A Genetic Family-Based Association Study of OLIG2 in Obsessive-compulsive Disorder

Author(s) -

S. Evelyn Stewart,

Jill Platko,

Jesen Fagerness,

Julie Birns,

Eric Jenike,

Jordan W. Smoller,

Roy H. Perlis,

Marion Leboyer,

Richard Delorme,

Nadia Chabane,

Scott L. Rauch,

Michael A. Jenike,

David L. Pauls

Publication year - 2007

Publication title -

archives of general psychiatry

Language(s) - English

Resource type - Journals

eISSN - 1538-3636

pISSN - 0003-990X

DOI - 10.1001/archpsyc.64.2.209

Subject(s) - single nucleotide polymorphism , haplotype , proband , minor allele frequency , genetics , olig2 , allele , allele frequency , genotype , biology , medicine , oligodendrocyte , gene , mutation , myelin , central nervous system

Obsessive-compulsive disorder (OCD) is a debilitating familial psychiatric illness with associated brain abnormalities in the white matter. The gene for oligodendrocyte lineage transcription factor 2 (OLIG2) is an essential regulator in the development of cells that produce white matter (myelin). The OLIG2 gene is also highly expressed in brain regions implicated in OCD.

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