Onset of Major Depression Associated With Acute Coronary Syndromes | Zendy

Alexander H. Glassman | Zendy; J. Thomas Bigger | Zendy; Michael Gaffney | Zendy; Peter A. Shapiro | Zendy; J. Robert Swenson | Zendy

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Onset of Major Depression Associated With Acute Coronary Syndromes

Author(s) -

Alexander H. Glassman,

J. Thomas Bigger,

Michael Gaffney,

Peter A. Shapiro,

J. Robert Swenson

Publication year - 2006

Publication title -

archives of general psychiatry

Language(s) - English

Resource type - Journals

eISSN - 1538-3636

pISSN - 0003-990X

DOI - 10.1001/archpsyc.63.3.283

Subject(s) - sertraline , major depressive disorder , major depressive episode , context (archaeology) , depression (economics) , medicine , antidepressant , acute coronary syndrome , population , odds ratio , placebo , psychiatry , psychology , mood , myocardial infarction , alternative medicine , macroeconomics , environmental health , pathology , hippocampus , economics , paleontology , biology

Depression observed following acute coronary syndrome (ACS) is common and associated with an increased risk of death. The Sertraline Antidepressant Heart Attack Trial (SADHART) tested the safety and efficacy of a selective serotonin reuptake inhibitor in this population. No evidence of harm was seen, and sertraline hydrochloride had an overall beneficial effect on mood that occurred primarily in patients with a history of episodes of major depressive disorder (MDD).

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