Modeling Sensitization to Stimulants in Humans | Zendy

Isabelle Boileau | Zendy; Alain Dagher | Zendy; Marco Leyton | Zendy; Roger N. Gunn | Zendy; Glen B. Baker | Zendy; Mirko Dikšić | Zendy; Chawki Benkelfat | Zendy

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Modeling Sensitization to Stimulants in Humans

Author(s) -

Isabelle Boileau,

Alain Dagher,

Marco Leyton,

Roger N. Gunn,

Glen B. Baker,

Mirko Dikšić,

Chawki Benkelfat

Publication year - 2006

Publication title -

archives of general psychiatry

Language(s) - English

Resource type - Journals

eISSN - 1538-3636

pISSN - 0003-990X

DOI - 10.1001/archpsyc.63.12.1386

Subject(s) - amphetamine , sensitization , raclopride , psychology , dopamine , neurochemical , putamen , ventral striatum , stimulant , dextroamphetamine , striatum , medicine , pharmacology , neuroscience , psychiatry

In animals, repeated exposure to stimulant drugs leads to an enhanced drug-induced psychomotor response and increased dopamine release. This phenomenon, known as sensitization, may confer vulnerability to drug addiction or drug-induced psychosis in humans. A similar phenomenon, referred to as endogenous sensitization, is also believed to play a role in the emergence of positive symptoms in patients with schizophrenia.

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