Early Visual Sensory Deficits as Endophenotypes for Schizophrenia
Author(s) -
Sherlyn Yeap,
Simon P. Kelly,
Pejman Sehatpour,
Elena Magno,
Daniel C. Javitt,
Hugh Garavan,
Jogin H. Thakore,
John J. Foxe
Publication year - 2006
Publication title -
archives of general psychiatry
Language(s) - English
Resource type - Journals
eISSN - 1538-3636
pISSN - 0003-990X
DOI - 10.1001/archpsyc.63.11.1180
Subject(s) - endophenotype , schizophrenia (object oriented programming) , psychology , proband , audiology , event related potential , visual processing , neuroscience , electroencephalography , scalp , sensory system , sensory processing , visual perception , visual n1 , first degree relatives , cognition , medicine , psychiatry , perception , family history , biology , biochemistry , anatomy , mutation , gene
The imperative to establish so-called endophenotypes-quantifiable measures of risk for neurological dysfunction-is a growing focus of research in schizophrenia. Electrophysiological markers of sensory processing, observable in human event-related potentials, hold great promise in this regard, lying closer to underlying physiology than descriptive clinical diagnostic tests.
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