Apolipoprotein E Genotype and Age-Related Myelin Breakdown in Healthy Individuals | Zendy

George Bartzokis | Zendy; Po H. Lu | Zendy; Daniel H. Geschwind | Zendy; Nancy Edwards | Zendy; Jim Mintz | Zendy; Jeffrey L. Cummings | Zendy

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Apolipoprotein E Genotype and Age-Related Myelin Breakdown in Healthy Individuals

Author(s) -

George Bartzokis,

Po H. Lu,

Daniel H. Geschwind,

Nancy Edwards,

Jim Mintz,

Jeffrey L. Cummings

Publication year - 2006

Publication title -

archives of general psychiatry

Language(s) - English

Resource type - Journals

eISSN - 1538-3636

pISSN - 0003-990X

DOI - 10.1001/archpsyc.63.1.63

Subject(s) - apolipoprotein e , myelin , corpus callosum , allele , white matter , internal capsule , genotype , biology , neuroscience , magnetic resonance imaging , medicine , psychology , genetics , central nervous system , disease , gene , radiology

Apolipoprotein E (APOE) genotype is the most influential Alzheimer disease (AD) risk factor after advanced age. The APOE4 alleles decrease and the APOE2 alleles increase age at onset of AD. Human and nonhuman primate data suggest that in midlife, the structural integrity of myelin sheaths begins breaking down, with an accelerating age-related trajectory most evident in the brain's later-myelinating association regions. This may result in a progressive "disconnection" of widely distributed neural networks that may underlie the age risk factor for AD.

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