Operation of the Schizophrenia Susceptibility Gene, Neuregulin 1, Across Traditional Diagnostic Boundaries to Increase Risk for Bipolar Disorder | Zendy

Elaine Green | Zendy; Rachel Raybould | Zendy; Stuart MacGregor | Zendy; Katherine GordonSmith | Zendy; Jess Heron | Zendy; Sally Hyde | Zendy; Detelina Grozeva | Zendy; Marian L. Hamshere | Zendy; Nigel Williams | Zendy; Michael J. Owen | Zendy; Michael O’Donovan | Zendy; Lisa Jones | Zendy; Ian Jones | Zendy; George Kirov | Zendy; Nick Craddock | Zendy

Open Access

Operation of the Schizophrenia Susceptibility Gene, Neuregulin 1, Across Traditional Diagnostic Boundaries to Increase Risk for Bipolar Disorder

Author(s) -

Elaine Green,

Rachel Raybould,

Stuart MacGregor,

Katherine GordonSmith,

Jess Heron,

Sally Hyde,

Detelina Grozeva,

Marian L. Hamshere,

Nigel Williams,

Michael J. Owen,

Michael O’Donovan,

Lisa Jones,

Ian Jones,

George Kirov,

Nick Craddock

Publication year - 2005

Publication title -

archives of general psychiatry

Language(s) - English

Resource type - Journals

eISSN - 1538-3636

pISSN - 0003-990X

DOI - 10.1001/archpsyc.62.6.642

Subject(s) - bipolar disorder , schizophrenia (object oriented programming) , haplotype , odds ratio , psychosis , neuregulin 1 , psychiatry , mood , case control study , family history , psychology , medicine , allele , genetics , biology , gene , receptor

Family and twin data suggest that, in addition to susceptibility genes specific for bipolar disorder or schizophrenia, genes exist that contribute to susceptibility across the traditional kraepelinian divide. Several studies have provided evidence that variation at the neuregulin 1 (NRG1) gene on chromosome 8p12 influences susceptibility to schizophrenia. The most consistent finding has been that one particular haplotype (the "core" haplotype) is overrepresented in cases compared with control subjects.

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