Early-Stage Visual Processing and Cortical Amplification Deficits in Schizophrenia | Zendy

Pamela D. Butler | Zendy; Vance Zemon | Zendy; Isaac Schechter | Zendy; Alice M. Saperstein | Zendy; Matthew J. Hoptman | Zendy; Kelvin O. Lim | Zendy; Nadine Revheim | Zendy; Gail Silipo | Zendy; Daniel C. Javitt | Zendy

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Early-Stage Visual Processing and Cortical Amplification Deficits in Schizophrenia

Author(s) -

Pamela D. Butler,

Vance Zemon,

Isaac Schechter,

Alice M. Saperstein,

Matthew J. Hoptman,

Kelvin O. Lim,

Nadine Revheim,

Gail Silipo,

Daniel C. Javitt

Publication year - 2005

Publication title -

archives of general psychiatry

Language(s) - English

Resource type - Journals

eISSN - 1538-3636

pISSN - 0003-990X

DOI - 10.1001/archpsyc.62.5.495

Subject(s) - parvocellular cell , neuroscience , psychology , schizophrenia (object oriented programming) , audiology , white matter , visual processing , psychiatry , medicine , magnetic resonance imaging , central nervous system , perception , radiology

Patients with schizophrenia show deficits in early-stage visual processing, potentially reflecting dysfunction of the magnocellular visual pathway. The magnocellular system operates normally in a nonlinear amplification mode mediated by glutamatergic (N-methyl-D-aspartate) receptors. Investigating magnocellular dysfunction in schizophrenia therefore permits evaluation of underlying etiologic hypotheses.

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