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Dose-Dependent Decrease of Activation in Bilateral Amygdala and Insula by Lorazepam During Emotion Processing
Author(s) -
Martin P. Paulus,
Justin S. Feinstein,
Gabriel Castillo,
Alan N. Simmons,
Murray B. Stein
Publication year - 2005
Publication title -
archives of general psychiatry
Language(s) - English
Resource type - Journals
eISSN - 1538-3636
pISSN - 0003-990X
DOI - 10.1001/archpsyc.62.3.282
Subject(s) - amygdala , functional magnetic resonance imaging , psychology , neuroscience , prefrontal cortex , insula , lorazepam , neuroimaging , anxiety , anxiolytic , cognition , psychiatry
Functional neuroimaging may elucidate the pathophysiologic features of anxiety disorders and the site of action of anxiolytic drugs. A large body of evidence suggests that the amygdala and associated limbic structures play a critical role in the expression of anxiety and may be treatment targets for anxiolytic drugs.

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