Open AccessHippocampal Complexin Proteins and Cognitive Dysfunction in Schizophrenia
Author(s) -
Ken Sawada,
Alasdair M. Barr,
Masato Nakamura,
Kunimasa Arima,
Clint E. Young,
Andrew J. Dwork,
Peter Falkai,
Anthony G. Phillips,
William G. Honer
Publication year - 2005
Publication title -
archives of general psychiatry
Language(s) - English
Resource type - Journals
eISSN - 1538-3636
pISSN - 0003-990X
DOI - 10.1001/archpsyc.62.3.263
Subject(s) - schizophrenia (object oriented programming) , hippocampal formation , hippocampus , neuroscience , biology , psychology , psychiatry
Converging neuroimaging and postmortem evidence indicates synaptic terminals are abnormal in schizophrenia. A putative molecular mechanism implicates abnormalities of proteins involved in the presynaptic secretory machinery, including the modulator proteins complexin I and complexin II.
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