Hippocampal Myo-inositol and Cognitive Ability in Adults With Down Syndrome | Zendy

Felix Beacher | Zendy; Andy Simmons | Zendy; Eileen Daly | Zendy; Verinder Prasher | Zendy; Claire Adams | Zendy; Maria Luisa Margallo-Lana | Zendy; Robin G. Morris | Zendy; Simon Lovestone | Zendy; Kieran C. Murphy | Zendy; Declan Murphy | Zendy

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Hippocampal Myo-inositol and Cognitive Ability in Adults With Down Syndrome

Author(s) -

Felix Beacher,

Andy Simmons,

Eileen Daly,

Verinder Prasher,

Claire Adams,

Maria Luisa Margallo-Lana,

Robin G. Morris,

Simon Lovestone,

Kieran C. Murphy,

Declan Murphy

Publication year - 2005

Publication title -

archives of general psychiatry

Language(s) - English

Resource type - Journals

eISSN - 1538-3636

pISSN - 0003-990X

DOI - 10.1001/archpsyc.62.12.1360

Subject(s) - inositol , hippocampal formation , dementia , down syndrome , alzheimer's disease , cognition , psychology , medicine , endocrinology , effects of sleep deprivation on cognitive performance , neuroscience , disease , psychiatry , receptor

Down syndrome (DS) is the most common genetic cause of mental retardation. However, the biological determinants of this are poorly understood. The serum sodium/myo-inositol cotransporter gene is located on chromosome 21, and myo-inositol affects neuronal survival and function. Nevertheless, few in vivo studies have examined the role of myo-inositol in DS.

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