Haplotype-Based Linkage of Tryptophan Hydroxylase 2 to Suicide Attempt, Major Depression, and Cerebrospinal Fluid 5-Hydroxyindoleacetic Acid in 4 Populations | Zendy

Zhifeng Zhou | Zendy; Alec Roy | Zendy; Robert H. Lipsky | Zendy; Kavi Kuchipudi | Zendy; Guanshan Zhu | Zendy; Julie Taubman | Zendy; MaryAnne Enoch | Zendy; Matti Virkkunen | Zendy; David Goldman | Zendy

Open Access

Haplotype-Based Linkage of Tryptophan Hydroxylase 2 to Suicide Attempt, Major Depression, and Cerebrospinal Fluid 5-Hydroxyindoleacetic Acid in 4 Populations

Author(s) -

Zhifeng Zhou,

Alec Roy,

Robert H. Lipsky,

Kavi Kuchipudi,

Guanshan Zhu,

Julie Taubman,

MaryAnne Enoch,

Matti Virkkunen,

David Goldman

Publication year - 2005

Publication title -

archives of general psychiatry

Language(s) - English

Resource type - Journals

eISSN - 1538-3636

pISSN - 0003-990X

DOI - 10.1001/archpsyc.62.10.1109

Subject(s) - tph2 , haplotype , tryptophan hydroxylase , proband , single nucleotide polymorphism , genetics , depression (economics) , psychiatry , psychology , biology , allele , serotonergic , gene , genotype , serotonin , mutation , receptor , macroeconomics , economics

Tryptophan hydroxylase 2 (TPH2) encodes the rate-limiting enzyme for brain serotonin biosynthesis. It was recently reported that the TPH2 haplotype was linked to depression in humans.

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