Correlation of Stable Elevations in Striatal μ-Opioid Receptor Availability in Detoxified Alcoholic Patients With Alcohol Craving | Zendy

Andreas Heinz | Zendy; Matthias Reimold | Zendy; Jana Wrase | Zendy; Derik Hermann | Zendy; Bernhard Croissant | Zendy; Götz Mundle | Zendy; Bernhard M. Dohmen | Zendy; Dieter H. Braus | Zendy; Günter Schumann | Zendy; HansJürgen Machulla | Zendy; Roland Bares | Zendy; Karl Mann | Zendy

Open Access

Correlation of Stable Elevations in Striatal μ-Opioid Receptor Availability in Detoxified Alcoholic Patients With Alcohol Craving

Author(s) -

Andreas Heinz,

Matthias Reimold,

Jana Wrase,

Derik Hermann,

Bernhard Croissant,

Götz Mundle,

Bernhard M. Dohmen,

Dieter H. Braus,

Günter Schumann,

HansJürgen Machulla,

Roland Bares,

Karl Mann

Publication year - 2005

Publication title -

archives of general psychiatry

Language(s) - English

Resource type - Journals

eISSN - 1538-3636

pISSN - 0003-990X

DOI - 10.1001/archpsyc.62.1.57

Subject(s) - craving , nucleus accumbens , opiate , alcohol dependence , striatum , naltrexone , ventral striatum , medicine , psychology , opioid , ventral tegmental area , endocrinology , receptor , alcohol , addiction , psychiatry , chemistry , dopamine , biochemistry , dopaminergic

The pleasant effects of food and alcohol intake are partially mediated by mu-opiate receptors in the ventral striatum, a central area of the brain reward system. Blockade of mu-opiate receptors with naltrexone reduces the relapse risk among some but not all alcoholic individuals.

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